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Deep learning is a promising approach to early DRV (Design Rule Violation) prediction. However, non-deterministic parallel routing hampers model training and degrades prediction accuracy. In this work, we propose a stochastic approach, called LGC-Net, to solve this problem. In this approach, we develop new techniques of Gaussian random field layer and focal likelihood loss function to seamlessly integrate Log Gaussian Cox process with deep learning. This approach provides not only statistical regression results but also classification ones with different thresholds without retraining. Experimental results with noisy training data on industrial designs demonstrate that LGC-Net achieves significantly better accuracy of DRV density prediction than prior arts. 

Abstract Background The mechanism by which immune cells regulate metastasis is unclear. Understanding the role of immune cells in metastasis will guide the development of treatments improving patient survival. Methods We used syngeneic orthotopic mouse tumour models (wild-type, NOD/scid and Nude), employed knockout ( CD8 and CD4 ) models and administered CXCL4. Tumours and lungs were analysed for cancer cells by bioluminescence, and circulating tumour cells were isolated from blood. Immunohistochemistry on the mouse tumours was performed to confirm cell type, and on a tissue microarray with 180 TNBCs for human relevance. TCGA data from over 10,000 patients were analysed as well. Results We reveal that intratumoral immune infiltration differs between metastatic and non-metastatic tumours. The non-metastatic tumours harbour high levels of CD8 + T cells and low levels of platelets, which is reverse in metastatic tumours. During tumour progression, platelets and CXCL4 induce differentiation of monocytes into myeloid-derived suppressor cells (MDSCs), which inhibit CD8 + T-cell function. TCGA pan-cancer data confirmed that CD8 low Platelet high patients have a significantly lower survival probability compared to CD8 high Platelet low . Conclusions CD8 + T cells inhibit metastasis. When the balance between CD8 + T cells and platelets is disrupted, platelets produce CXCL4, which induces MDSCs thereby inhibiting the CD8 + T-cell function.